Gross/Macroscopic Variations and Conditions
Variations in Size and Shape
Large for gestational age / overweight placentas

Topic Completed: 1 October 2011

Minor changes: 28 October 2020

Copyright: 2002-2021,, Inc.

PubMed Search: Large for gestational age placenta [title]

Mandolin S. Ziadie, M.D.
Page views in 2020: 743
Page views in 2021 to date: 59
Cite this page: Ziadie MS. Large for gestational age / overweight placentas. website. Accessed January 24th, 2021.
Definition / general
  • Placenta weight > 90th percentile for estimated gestational age
  • Usually due to edema as a result of fetal or maternal factors
  • Fetal factors: acute antenatal hypoxia, including low Apgar scores, respiratory distress syndrome, neurologic abnormalities (may persist), hydrops / neonatal death (erythroblastosis fetalis, tumors or fetal renal vein thrombosis), chronic intrauterine infection, immunohemolytic anemia, fetomaternal hemorrhage and polyhydramnios (Hum Pathol 1987;18:387)
  • Maternal factors: diabetes, anemia, malnutrition, retroplacental hematoma and TORCH infections
Gross description
  • Bulky, overweight placenta
Microscopic (histologic) description
  • May include extensive villous edema, chorangiosis and villous dysmaturity (distal villous hypoplasia)
Back to top
Image 01 Image 02