Placenta associated uterine conditions

Placental site subinvolution

Topic Completed: 1 November 2011

Minor changes: 29 October 2020

Copyright: 2002-2021,, Inc.

PubMed Search: Placental site subinvolution

Mandolin S. Ziadie, M.D.
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Cite this page: Ziadie MS. Placental site subinvolution. website. Accessed November 29th, 2021.
Definition / general
  • Delayed / incomplete sloughing of the modified spiral arteries in the superficial myometrium beneath the placental attachment site
  • Important cause of late postpartum bleeding
  • May be due to deficiency in immunologic factors necessary for normal involution of uteroplacental arteries
Microscopic (histologic) description
  • Curettings show large, dilated vessels that lack a medial coat and are partially / completely thrombosed
  • Trophoblasts may be present
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