Gestational trophoblastic disease

Abnormal (nonmolar) villous lesions

Mesenchymal dysplasia

Last author update: 1 October 2011
Last staff update: 29 October 2020

Copyright: 2002-2024,, Inc.

PubMed Search: Mesenchymal dysplasia placenta

Mandolin S. Ziadie, M.D.
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Cite this page: Ziadie MS. Mesenchymal dysplasia. website. Accessed May 19th, 2024.
Definition / general
  • Rare disorder characterized by an enlarged, abnormal placenta due to overgrowth and vascular abnormalities
  • May be associated with fetal overgrowth syndromes, omphalocele or mosaicism
Case reports
Gross description
  • Bulky placenta with a "bed of yarn" appearance to the maternal surface
  • Large, dilated vessels on the chorionic plate that may be thrombosed or have aneurysms
  • Resembles a partial mole
Gross images

Contributed by Govindaswamy Koteeswaran, M.D.

Various images

Microscopic (histologic) description
  • Dilated thick walled chorionic plate vessels with fibromuscular hyperplasia
  • Stem villi are enlarged and hypervascular with hydropic stroma and central cisterns that may be lined by lymphatic endothelium (Placenta 2009;30:654) and are filled with gelatinous material
  • No trophoblastic hyperplasia is present
  • Intermediate villi show chorangiomatosis-like changes with abnormal vascular branching / dilatation
  • Terminal villi may be normal or immature
Microscopic (histologic) images

Contributed by Govindaswamy Koteeswaran, M.D.

Various images

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