Table of Contents
Definition / general | Case reports | Microscopic (histologic) description | Electron microscopy descriptionCite this page: Ziadie MS. Sickle cell disease. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/placentasicklecelldisease.html. Accessed October 1st, 2023.
Definition / general
- Maternal disorder of hemoglobin synthesis associated with an increased risk of intrauterine fetal demise or growth restriction
Case reports
- 28 year old woman with sickle cell trait (Arch Pathol Lab Med 2000;124:1565)
Microscopic (histologic) description
- Multiple findings include infarction, sickled red blood cells, intervillous hemorrhage, Tenney-Parker change, decidual vasculopathy, villous fibrosis
Electron microscopy description
- Umbilical vein shows smooth muscle proliferation, increase in basement membrane thickness, necrosis reduplication of inner elastic lamina (Hum Pathol 1999;30:13)