Nonneoplastic placental conditions and abnormalities

Placental findings in specific conditions

Sickle cell disease

Last author update: 1 October 2011
Last staff update: 31 August 2020

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PubMed Search: Sickle cell disease placenta

Mandolin S. Ziadie, M.D.
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Cite this page: Ziadie MS. Sickle cell disease. website. Accessed December 1st, 2022.
Definition / general
  • Maternal disorder of hemoglobin synthesis associated with an increased risk of intrauterine fetal demise or growth restriction
Case reports
Microscopic (histologic) description
  • Multiple findings include infarction, sickled red blood cells, intervillous hemorrhage, Tenney-Parker change, decidual vasculopathy, villous fibrosis
Electron microscopy description
  • Umbilical vein shows smooth muscle proliferation, increase in basement membrane thickness, necrosis reduplication of inner elastic lamina (Hum Pathol 1999;30:13)
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