Nonneoplastic placental conditions and abnormalities


Thrombosis of fetal arteries

Last author update: 1 November 2011
Last staff update: 31 August 2020

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PubMed Search: Thrombosis of fetal arteries placenta

Mandolin S. Ziadie, M.D.
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Cite this page: Ziadie MS. Thrombosis of fetal arteries. website. Accessed June 1st, 2023.
Definition / general
  • Thrombosis of fetal vessels results in fibrosis of downstream villi
  • Thrombi may also embolize to fetal organs, resulting in perinatal asphyxia and an increased risk of neurologic injury
  • More common in diabetic pregnancies, often associated with increased syncytial knots, fibrotic villi, Langhans cells and villous fibrinoid necrosis
Gross description
  • Triangular or hemispheric pale areas, seen better after formalin fixation or otherwise similar to remaining placenta
Microscopic (histologic) description
  • Occlusive thrombi in large stem vessels accompanied by downstream changes, including loss of vascularity and fibrosis
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