Nonneoplastic placental conditions and abnormalities


Distal villous hyperplasia (villous dysmaturity / delayed villous maturation)

Last author update: 1 October 2011
Last staff update: 29 October 2020

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PubMed Search: Distal villous hyperplasia OR villous dysmaturity OR delayed villous maturation

Mandolin S. Ziadie, M.D.
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Cite this page: Ziadie MS. Distal villous hyperplasia (villous dysmaturity / delayed villous maturation). website. Accessed June 1st, 2023.
Definition / general
  • Abnormal villous maturation associated with diabetes
  • Neonatal hepatitis should be suspected if pigment laden Hofbauer cells are present
Gross description
  • Placenta is usually large for gestational age
Microscopic (histologic) description
  • Terminal villi may be hypervascular and edematous with reduced numbers of syncytial knots
  • Trophoblast lacks normal syncytiotrophoblast
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