Placenta
Nonneoplastic placental conditions and abnormalities
Noninfectious
Distal villous hyperplasia (villous dysmaturity / delayed villous maturation)
Author: Mandolin S. Ziadie, M.D.
Last author update: 1 October 2011
Last staff update: 29 October 2020
Copyright: 2002-2023, PathologyOutlines.com, Inc.
PubMed Search: Distal villous hyperplasia OR villous dysmaturity OR delayed villous maturation
Cite this page: Ziadie MS. Distal villous hyperplasia (villous dysmaturity / delayed villous maturation). PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/placentavillousdysmaturity.html. Accessed June 1st, 2023.
Definition / general
- Abnormal villous maturation associated with diabetes
- Neonatal hepatitis should be suspected if pigment laden Hofbauer cells are present
Gross description
- Placenta is usually large for gestational age
Microscopic (histologic) description
- Terminal villi may be hypervascular and edematous with reduced numbers of syncytial knots
- Trophoblast lacks normal syncytiotrophoblast
