Nonneoplastic placental conditions and abnormalities


Distal villous hyperplasia (villous dysmaturity / delayed villous maturation)

Topic Completed: 1 October 2011

Minor changes: 29 October 2020

Copyright: 2002-2021,, Inc.

PubMed Search: Distal villous hyperplasia OR villous dysmaturity OR delayed villous maturation

Mandolin S. Ziadie, M.D.
Page views in 2020: 1,875
Page views in 2021 to date: 2,099
Cite this page: Ziadie MS. Distal villous hyperplasia (villous dysmaturity / delayed villous maturation). website. Accessed November 27th, 2021.
Definition / general
  • Abnormal villous maturation associated with diabetes
  • Neonatal hepatitis should be suspected if pigment laden Hofbauer cells are present
Gross description
  • Placenta is usually large for gestational age
Microscopic (histologic) description
  • Terminal villi may be hypervascular and edematous with reduced numbers of syncytial knots
  • Trophoblast lacks normal syncytiotrophoblast
Back to top
Image 01 Image 02