Pleura & peritoneum

Pleura mesothelial tumors


Topic Completed: 1 November 2013

Minor changes: 12 April 2021

Copyright: 2003-2021,, Inc.

PubMed Search: Desmoplastic mesothelioma

See Also: Mesothelioma

Vaidehi Avadhani, M.D.
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Page views in 2021 to date: 2,121
Cite this page: Avadhani V. Mesothelioma-desmoplastic. website. Accessed November 27th, 2021.
Definition / general
  • > 50% of tumor shows desmoplastic pattern
  • 5 - 10% of malignant mesotheliomas
  • Note: DMM may refer to desmoplastic or diffuse malignant mesothelioma
Case reports
Microscopic (histologic) description
  • Characteristic dense collagenized tissue separated by atypical cells arranged in a storiform or haphazard pattern (J Clin Pathol 1992;45:295), comprising > 50% of tumor
  • Presence of sarcomatoid areas, bland collagen, necrosis, stromal / fat invasion help differentiate from organizing pleuritis (Am J Surg Pathol 2011;35:1823)
  • Paucicellularity of lesion may lead to misdiagnosis
Microscopic (histologic) images

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Storiform pattern

Positive stains
Negative stains
  • CD31 (positive in angiosarcoma), CD34 (positive in solitary fibrous tumor, Hum Pathol 1995;26:428)
  • S100 (positive in neurogenic tumors, mesotheliomas may show focal staining)
  • CD45
  • Some muscle markers are focally positive
Electron microscopy description
  • Sarcomatous mesotheliomas including desmoplastic type have no specific ultrastructural features
Differential diagnosis
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