Pleura & peritoneum
Pleura other tumors
Solitary fibrous tumor

Topic Completed: 1 December 2013

Minor changes: 29 January 2021

Copyright: 2003-2021,, Inc.

PubMed Search: Solitary fibrous tumor[TI] pleura[TI] full text[sb]

Nat Pernick, M.D.
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Cite this page: Pernick N. Solitary fibrous tumor. website. Accessed May 16th, 2021.
Definition / general
  • Also called localized fibrous tumor
  • Formerly called benign or solitary fibrous mesothelioma
  • Confined to surface of lung, usually does not produce a pleural effusion
  • Associated with pulmonary osteoarthropathy, digital clubbing and hypoglycemia, which regress after tumor resection
  • Most likely fibroblastic and not mesothelial in origin, arising from submesothelial mesenchyme
  • Not associated with asbestos
  • May recur locally
  • May cause death due to extensive intrathoracic growth or if malignant
  • Malignant cases are very rare
Case reports
  • Surgical excision
Gross description
  • Arises from pleural surface by a pedicle
  • Solitary, well circumscribed, may be encapsulated
  • Composed of dense, gray-white fibrous tissue with firm, whorled cut surface (like uterine leiomyoma), large tumors may be cystic and hemorrhagic
Gross images

Images hosted on other servers:

Smooth rounded mass

Microscopic (histologic) description
  • Fibroblast-like cells with variable cellularity in collagenous, keloid-like stroma, reticulin fibers, hemangiopericytoma-like vessels
  • No / rare mitotic activity, no atypia
  • May entrap mesothelium or epithelium at periphery
  • May have focal or marked myxoid change with bland spindle cells in myxoid, vascularized stroma (Mod Pathol 1999;12:463)
  • Malignant cases show increased cellularity, marked nuclear atypia, prominent necrosis, high mitotic activity
Microscopic (histologic) images

Case #358

Tumor with malignant behavior

Tumor with malignant behavior

Positive stains
Differential diagnosis
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