Prostate gland & seminal vesicles

Other carcinomas

Basal cell carcinoma

Topic Completed: 1 February 2012

Minor changes: 8 September 2020

Copyright: 2003-2022,, Inc.

PubMed search: prostate basal cell carcinoma

Komal Arora, M.D.
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Cite this page: Arora K. Basal cell carcinoma. website. Accessed January 22nd, 2022.
Definition / general
  • Also known as adenoid basal, adenoid cystic-like tumor, adenoid basal proliferation of uncertain significance
  • Resembles to some extent the salivary gland tumor
  • Usually indolent; cases with aggressive behavior often have large solid nests with central necrosis, high Ki67%, less staining with basal cell markers (Am J Surg Pathol 2007;31:697)
Case reports
Microscopic (histologic) description
  • Expansive (not circumscribed) growth pattern
  • Multinodular, basaloid cells in clusters, some with punched out lumens
  • Surrounding fibromyxoid stroma, squamous differentiation, merges with basal cell hyperplasia
  • May be associated with minor component of usual type prostatic adenocarcinoma
  • Considered malignant if extensive infiltration between normal prostate gland, extension out of the prostate, perineural invasion, necrosis or metastases
  • Gleason grading of these tumors is not recommended
Positive stains
  • 34betaE12
  • p63
Negative stains
  • PSA / PAP
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