Prostate gland & seminal vesicles

Acinar / ductal adenocarcinomas

Atrophic adenocarcinoma



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Last staff update: 4 September 2020

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PubMed search: prostatic atrophic adenocarcinoma

Komal Arora, M.D.
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Cite this page: Arora K. Atrophic adenocarcinoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/prostateatrophic.html. Accessed June 2nd, 2023.
Definition / general
  • Proliferation of malignant acini that architecturally resembles atrophy or postatrophic hyperplasia but retains the diagnostic cytologic features of cancer
  • Usually NOT associated with hormone therapy
Microscopic (histologic) description
  • Acini are round, often dilated and distorted and lined by flattened attenuated epithelium with scant cytoplasm and infiltrative growth pattern
  • Nuclear enlargement and prominent nucleoli present
  • Atrophic features represent mean 25% of total tumor (range 10-90%) in needle biopsies and prostatectomy specimens
  • Usually Gleason score 6-7 (Am J Surg Pathol 1997;21:289, Am J Clin Pathol 1998;109:695)
  • Also luminal eosinophilic proteinaceous secretions, blue mucin, crystalloids, apocrine blebs, collagenous micronodules, high-grade PIN within two high-power fields (Am J Surg Pathol 1997;21:931)
Differential diagnosis
  • Benign atrophy: no associated carcinoma, small and indistinct nucleoli, basal layer present but may be fragmented
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