Prostate gland & seminal vesicles
Acinar / ductal adenocarcinoma
Atrophic adenocarcinoma

Topic Completed: 1 March 2012

Minor changes: 27 February 2019

Copyright: 2003-2019,, Inc.

PubMed search: prostatic atrophic adenocarcinoma

Komal Arora, M.D.
Page views in 2019: 1,307
Page views in 2020 to date: 603
Cite this page: Arora K. Atrophic adenocarcinoma. website. Accessed August 12th, 2020.
Definition / general
  • Proliferation of malignant acini that architecturally resembles atrophy or postatrophic hyperplasia but retains the diagnostic cytologic features of cancer
  • Usually NOT associated with hormone therapy
Microscopic (histologic) description
  • Acini are round, often dilated and distorted and lined by flattened attenuated epithelium with scant cytoplasm and infiltrative growth pattern
  • Nuclear enlargement and prominent nucleoli present
  • Atrophic features represent mean 25% of total tumor (range 10-90%) in needle biopsies and prostatectomy specimens
  • Usually Gleason score 6-7 (Am J Surg Pathol 1997;21:289, Am J Clin Pathol 1998;109:695)
  • Also luminal eosinophilic proteinaceous secretions, blue mucin, crystalloids, apocrine blebs, collagenous micronodules, high-grade PIN within two high-power fields (Am J Surg Pathol 1997;21:931)
Microscopic (histologic) images

Images hosted on other servers:

Various images

Differential diagnosis
  • Benign atrophy: no associated carcinoma, small and indistinct nucleoli, basal layer present but may be fragmented
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