Prostate gland & seminal vesicles

Acinar / ductal adenocarcinoma

Atrophic adenocarcinoma

Topic Completed: 1 March 2012

Minor changes: 4 September 2020

Copyright: 2003-2021,, Inc.

PubMed search: prostatic atrophic adenocarcinoma

Komal Arora, M.D.
Page views in 2020: 1,155
Page views in 2021 to date: 1,469
Cite this page: Arora K. Atrophic adenocarcinoma. website. Accessed December 7th, 2021.
Definition / general
  • Proliferation of malignant acini that architecturally resembles atrophy or postatrophic hyperplasia but retains the diagnostic cytologic features of cancer
  • Usually NOT associated with hormone therapy
Microscopic (histologic) description
  • Acini are round, often dilated and distorted and lined by flattened attenuated epithelium with scant cytoplasm and infiltrative growth pattern
  • Nuclear enlargement and prominent nucleoli present
  • Atrophic features represent mean 25% of total tumor (range 10-90%) in needle biopsies and prostatectomy specimens
  • Usually Gleason score 6-7 (Am J Surg Pathol 1997;21:289, Am J Clin Pathol 1998;109:695)
  • Also luminal eosinophilic proteinaceous secretions, blue mucin, crystalloids, apocrine blebs, collagenous micronodules, high-grade PIN within two high-power fields (Am J Surg Pathol 1997;21:931)
Differential diagnosis
  • Benign atrophy: no associated carcinoma, small and indistinct nucleoli, basal layer present but may be fragmented
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