Prostate gland & seminal vesicles

Other nonneoplastic lesions


Editorial Board Member: Maria Tretiakova, M.D., Ph.D.
Andres Matoso, M.D.

Topic Completed: 1 March 2017

Minor changes: 30 October 2020

Copyright: 2003-2021,, Inc.

PubMed search: prostatic calculi

Andres Matoso, M.D.
Page views in 2020: 399
Page views in 2021 to date: 462
Cite this page: Matoso A. Calculi. website. Accessed December 2nd, 2021.
Definition / general
  • Rare in children, infrequent < age 40, common > age 50
  • May be solitary but usually occur in clusters and are associated with nodular hyperplasia, prostatic carcinoma, metabolic abnormalities or other abnormalities (Prostate 1985;7:91)
  • Identified in 7% of prostates with nodular hyperplasia
  • Stones usually contain phosphate salts of calcium, magnesium, potassium, calcium carbonate or calcium oxalate; stones in enlarged prostatic utricles contain hydroxyapatite (J Androl 2012;33:45)
  • Corpora amylacea may act as nidus for stone formation
  • Radiopaque, are detected by Xray
  • Rarely are infected and cause abscesses
Essential features
  • Uncommon in children and under age 40
  • Usually associated with benign prostatic hyperplasia
  • Primary or endogenous when originate in the prostate; secondary or exogenous when originate outside the prostate (kidney, bladder)
  • Chemical composition of hydroxylapatite / carboapatite and whitlockite suggest prostatic origin; uric acid or oxalic compounds are more common in exogenous calculi
  • Lithiasis, calculi
ICD coding
  • N42.0
  • Uncommon in children and under age 40
  • Prostatic ducts, urethra
  • Primary lithiasis appears to originate from phosphocalcifications of corpora amylacea
  • Can form in a prostatic lodge of TURP with distal obstruction
  • Associated with diseases that cause lower urinary tract obstruction
Clinical features
  • Incidental finding on TURP or prostatectomy specimen
  • Lower urinary tract symptoms in larger calculi obstructing or irritating the urethra
  • Radiology
  • Urethrocystoscopy
Radiology description
  • Seen on Xray
Prognostic factors
  • No prognostic significance
  • TURP, prostatectomy, endoscopic removal, endoscopic lithotripsy
Gross images

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Prostate stones

Differential diagnosis
  • Foreign body
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