Prostate gland & seminal vesicles

Acinar / ductal adenocarcinoma

Foamy gland adenocarcinoma

Topic Completed: 1 March 2012

Minor changes: 4 September 2020

Copyright: 2003-2021,, Inc.

PubMed search: prostatic foamy gland adenocarcinoma

Komal Arora, M.D.
Page views in 2020: 3,091
Page views in 2021 to date: 3,283
Cite this page: Arora K. Foamy gland adenocarcinoma. website. Accessed December 6th, 2021.
Definition / general
Microscopic (histologic) description
  • Abundant xanthomatous cytoplasm, small hyperchromatic nuclei, minimal / no atypia, pink luminal secretions
  • Hyperchromatic nuclei may make nucleoli difficult to see
  • Cytoplasm differs between malignant and benign glands
  • No obvious basal layer compared to normal glands
  • Foamy morphology comprises most of cancer
  • Usually Gleason score 3+3=6, occasionally Gleason 7 or higher (Am J Surg Pathol 2009;33:583)
  • Needle biopsies may have only a few atypical foamy glands (Ann Diagn Pathol 2008;12:349)
Positive stains
Negative stains
  • Mucicarmine
  • PAS
  • Lipid
Electron microscopy description
  • Intracytoplasmic vesicles
  • Polyribosomes
Differential diagnosis
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