Prostate gland & seminal vesicles

Mesenchymal tumors


Last author update: 1 January 2017
Last staff update: 11 January 2021

Copyright: 2003-2023,, Inc.

PubMed search: prostatic leiomyosarcoma

Kenneth A. Iczkowski, M.D.
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Cite this page: Iczkowski KA. Leiomyosarcoma. website. Accessed September 30th, 2023.
Definition / general
  • The most common malignant spindle cell tumor of the prostate
Essential features
  • Rare, but the most common prostatic sarcoma
  • Aggressive
  • Nonsarcomatous spindle cell proliferations must be ruled out
  • Leiomyosarcoma is the most common prostatic sarcoma in adults; it may also occur in children
  • Fewer than 200 cases are reported
Clinical features
  • Tumor causes obstruction, and involves adjacent organs
  • Can initially present with chest metastasis (J Cancer Res Ther 2013;9:743) or in other odd ways
  • Tends to recur
  • Metastases to liver and lung
  • Mean survival 3 - 4 years
Microscopic (histologic) description
  • A spindle cell proliferation with atypia and mitotic activity
  • Focal necrosis may be seen
Microscopic (histologic) images

Contributed by Athanase Billis, M.D.

Various images

Images hosted on other servers:

Giant neoplastic cells (a) and multifocal necrosis (b)

Smooth muscle actin (a) and vimentin (b)

Positive stains
Negative stains
Molecular / cytogenetics description
  • Cytogenetics may disclose chromosome 2, 3, 9, 11 and 19 clonal rearrangements
Differential diagnosis
Additional references
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