Prostate gland & seminal vesicles

Benign mimickers of carcinoma


Topic Completed: 1 August 2015

Minor changes: 4 September 2020

Copyright: 2003-2020,, Inc.

PubMed Search: Paraganglion [title]

Andres Matoso, M.D.
Page views in 2020: 440
Page views in 2021 to date: 552
Cite this page: Matoso A. Paraganglion. website. Accessed December 8th, 2021.
Definition / general
  • Group of neuroendocrine cells derived from neural crest
  • Usually located in posterolateral soft tissue outside of prostate
  • Seen in radical prostatectomy specimens and rarely in prostate needle biopsies, or in smooth muscle of bladder neck in transurethral resections of prostate or bladder
Microscopic (histologic) description
  • Group of cells with clear, vacuolated or amphophilic cytoplasm with a delicate blood vessel meshwork
  • Nuclei may show prominent nucleoli or degenerative endocrine type atypia
Microscopic (histologic) images
Contributed by Andres Matoso, M.D.
Missing Image

Chromogranin A+

Differential diagnosis
  • The main differential diagnosis is with Gleason pattern 5 prostate cancer
    • The degenerative type atypia in paraganglions is helpful when present; also absence of surrounding prostate glands
    • Immunohistochemistry for prostate markers and cytokeratin is helpful
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