Prostate gland & seminal vesicles


Features to report

Topic Completed: 1 June 2012

Minor changes: 4 September 2020

Copyright: 2003-2021,, Inc.

PubMed search: prostatic features[title]

Komal Arora, M.D.
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Cite this page: Arora K. Features to report. website. Accessed December 3rd, 2021.
Definition / general
  • Structures included in specimen (prostate [complete or not], seminal vesicles, vas deferens, bladder neck)
  • Weight, size in 3 dimensions
  • Histologic type and location of tumor (if any)
  • Gleason pattern/grade and score
  • % of prostate involved by tumor (need not give volume but an indication of minute vs. voluminous)
  • Presence of perineural invasion (diameter may be prognostic factor (Hum Pathol 2001;32:828)
  • Presence of angiolymphatic invasion (Am J Surg Pathol 1996;20:1351, J Urol 2005;174:2181)
  • Presence of extraprostatic tissue invasion
  • Presence of high grade PIN
  • Margins
  • Lymph nodes (# involved, # sampled) and diameter of largest metastasis (Am J Surg Pathol 1998;22:1491)
  • Acute or chronic inflammation (often doesn’t correlate with clinical prostatitis)
  • Granulomatous prostatitis (may elevate PSA, produce suspicious feeling gland)
  • Note: extranodal tumor extension not related to survival (Mod Pathol 2000;13:113)

Biopsies (core or transurethral prostate resection):
  • Histologic type
  • Gleason primary and secondary grades and total score
  • # cores involved, # cores total
  • % of prostatic tissue involved by tumor or total linear mm of carcinoma / total linear mm of tissue
  • Presence of perineural, angiolymphatic, periprostatic fat invasion, seminal vesicle invasion, extraprostatic tissue invasion
  • Presence of high grade PIN (if no carcinoma, report # of cores involved and pattern of high grade PIN)
  • Therapy related changes

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