Salivary glands
Diffuse infiltrative lymphocytosis syndrome

Topic Completed: 1 October 2015

Minor changes: 30 October 2020

Copyright: 2002-2021,, Inc.

PubMed Search: Diffuse infiltrative lymphocytosis syndrome[TIAB]

Sally Tanakchi, M.D.
F. Zahra Aly, M.D., Ph.D.
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Cite this page: Tanakchi S, Aly FZ. Diffuse infiltrative lymphocytosis syndrome. website. Accessed January 23rd, 2021.
Definition / general
  • Clinical mimic of Sjögren syndrome causing parotid gland enlargement, dry eye and dry mouth
  • Associated with HIV and persistent CD8+ lymphocytosis
  • Frequently involves salivary glands (present in 1 - 6% of U.S. HIV+ patients versus up to 50% in Africa) and lungs, also affects lacrimal glands, kidney, muscle nerve, liver, GI and breast
  • In lungs, may radiographically present as diffuse bilateral pulmonary infiltrates mimicking pneumocystis jiroveci
  • DILS may be less prevalent now due to HAART therapy which decreases the CD8 counts
  • Proposed diagnostic criteria for diagnosis include:
    • HIV seropositivity
    • Bilateral salivary gland infiltration to salivary gland
Case reports
Microscopic (histologic) description
  • Resembles Sjögren syndrome
  • Lymphocytic infiltration of CD8+ cells
  • Less destruction of salivary gland than Sjögren syndrome
  • Salivary ductal epithelial atypia is common in the Cameroon in advanced HIV patients
  • Lymphoepithelial cysts are frequently, characterized by follicular hyperplasia and cystic dilation of ducts lined by pseudostratified squamous epithelium
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