Salivary glands

Nonneoplastic tumors/tumor-like conditions


Topic Completed: 1 October 2015

Minor changes: 7 April 2021

Copyright: 2002-2021,, Inc.

PubMed Search: Amyloidosis[TI] salivary

Sally Tanakchi, M.D.
F. Zahra Aly, M.D., Ph.D.
Page views in 2020: 534
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Cite this page: Tanakchi S, Aly FZ. Amyloidosis. website. Accessed October 23rd, 2021.
Definition / general
  • Amyloidosis can develop either as a local or systemic disease
  • In head and neck region, the larynx is most common site of involvement
  • Salivary gland amyloidosis is usually secondary and involves a minor salivary gland
  • Involvement of a major salivary gland by amyloidosis is very rare
    • Symptoms of involvement can mimic Sjögren syndrome
  • Biopsy of minor salivary gland (labial gland) is recommended to demonstrate systemic amyloidosis, with a sensitivity of 60 - 100%
Case reports
Microscopic (histologic) description
  • Gold standard to diagnose amyloidosis is demonstration of Congo red positivity with apple green birefringence on polarization
  • Positivity for amyloid A or amyloid P antibody staining is used for classification
Microscopic (histologic) images

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Labial salivary gland

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Congo red, gingiva

Additional references
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