Salivary glands

Primary salivary gland neoplasms



Topic Completed: 1 September 2012

Minor changes: 13 April 2021

Copyright: 2003-2021,, Inc.

PubMed Search: Keratocystoma

Adriana Handra-Luca, M.D., Ph.D.
Page views in 2020: 635
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Cite this page: Handra-Luca A. Keratocystoma. website. Accessed December 3rd, 2021.
Definition / general
Clinical features
  • Very rare neoplasm of children / adults, < 20 cases reported
  • Usually parotid gland; may derive from salivary ducts undergoing squamous metaplasia
  • Excision appears to be adequate treatment
Case reports
Microscopic (histologic) description
  • Benign tumor with multicystic spaces, without lobular architecture, lined by squamous cells with focal solid epithelial nests
  • Parakeratotic and orthokeratotic keratinization without a granular layer
  • Outer layer has bud-like protrusions
  • Cells have abundant eosinophilic cytoplasm and bland, uniform nuclei
  • May have collageneous stroma, expansive growth
  • Focal foreign body reaction against keratin
  • Occasional normal mitotic figures
  • No necrosis, no invasion, no angiolymphatic invasion, no perineurial invasion, no atypia, no mucous cells
Microscopic (histologic) images

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37 year old man with parotid tumor

Positive stains
Differential diagnosis
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