Salivary glands

Topic Completed: 1 September 2012

Minor changes: 2 November 2020

Copyright: 2003-2021,, Inc.

PubMed Search: Lymphoma[TI] salivary[TI]

Adriana Handra-Luca, M.D.
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Cite this page: Handra-Luca A. Lymphoma-general. website. Accessed March 4th, 2021.
Definition / general
  • Represent 5% extranodal lymphoma, 3% of salivary gland neoplasms, 10% of malignant salivary gland tumors
Clinical features
  • Mean age 63 years
  • Primary lymphomas may arise from intraparotid lymph node or within parotid or submandibular gland
  • Unilateral masses, often diffuse large B cell lymphoma (may arise from MALT, Leuk Lymphoma 2007;48:1793), follicular lymphoma, MALT or SLL / CLL
  • Increased risk with autoimmune disease or HIV
  • Usually good prognosis (Acta Haematol 2004;112:203)
Case reports
Microscopic (histologic) images

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Primary T cell lymphoma

Cytology description
  • Low grade lymphoma: monotonous population of atypical small to medium sized lymphocytes, ex: extranodal marginal zone lymphoma, follicular lymphoma
  • High grade lymphoma: diffuse proliferation of large atypical cells, ex: diffuse large B cell lymphoma
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