Salivary glands
Primary salivary gland neoplasms
Malignant
Oncocytic carcinoma
Author: Adriana Handra-Luca, M.D.
Topic Completed: 1 September 2012
Minor changes: 2 November 2020
Copyright: 2003-2021, PathologyOutlines.com, Inc.
PubMed Search: Oncocytic carcinoma salivary
Table of Contents
Definition / general | Clinical features | Case reports | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Differential diagnosisCite this page: Handra-Luca A. Oncocytic carcinoma. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/salivaryglandsoxyphiliccarcinoma.html. Accessed March 4th, 2021.
Definition / general
- Malignant counterpart of oncocytoma
- Also called malignant oncocytoma, oxyphilic carcinoma
Clinical features
- Very rare; usually males, tumor of parotid or submandibular gland
- High grade tumor that arises de novo or in oncocytoma (J Oral Pathol Med 1998;27:225)
- May occur after radiotherapy (J Exp Clin Cancer Res 1998;17:65)
- Disease specific 5 year survival of 54% (Oral Oncol 2010;46:773)
- May recur, have regional / distant metastases (including bone)
Case reports
- 53 year old man with oncocytic carcinoma ex pleomorphic adenoma (Head Neck Pathol 2010;4:49)
- 67 year old man with metastatic tumor to bone (South Med J 2009;102:659)
Microscopic (histologic) description
- Adenocarcinoma type architecture, malignant appearing oncocytic cells with infiltrative growth, mucus production, perineural invasion
- Atypia, mitotic figures
- May occur in pleomorphic adenoma
Microscopic (histologic) images
Images hosted on other servers:
Oncocytic carcinoma ex pleomorphic carcinoma
Various images
Positive stains
- PTAH, p63 (Head Neck Pathol 2007;1:123), MA903; increased MIB1 / Ki67 rate
Differential diagnosis
- Renal cell carcinoma: p63 negative
