Salivary glands
Primary salivary gland neoplasms
Salivary duct papilloma

Topic Completed: 1 September 2012

Minor changes: 12 March 2020

Copyright: 2003-2020,, Inc.

PubMed Search: Salivary duct papilloma

Adriana Handra-Luca, M.D.
Page views in 2019: 1,157
Page views in 2020 to date: 755
Cite this page: Handra-Luca A. Salivary duct papilloma. website. Accessed August 11th, 2020.
Definition / general
  • Rare, benign papillary proliferations of bland cuboidal / columnar epithelial cells with fibrovascular cores, inflammation
  • Also called intraductal papilloma, intraductal papillary tumor
  • Usually in minor salivary glands, rare in parotid or sublingual glands
Clinical features
Case reports
  • Surgery; does not recur.
Microscopic (histologic) description
  • Papillary proliferations of bland cuboidal / columnar epithelial cells with fibrovascular cores, inflammation, few mitoses
  • May have acinar cell differentiation, ductal cyst by obliteration, malignant transformation to adenocarcinoma
Microscopic (histologic) images

Images hosted on other servers:

Intraductal papillary proliferation

Papillary, tubular and solid patterns


Smooth muscle actin demonstrates no invasion

Upper lip tumor has papillary
proliferation of epithelial cells with
numerous intricately branching
fronds in cystically dilated duct lumen

Cytology description
  • Compact clusters of papillary monomorphic columnar cells with abundant finely vacuolar cytoplasm; oval nuclei basally located, indistinct nucleol; no squamous cells (Acta Cytol 1999;43:457)
Positive stains
Negative stains
Electron microscopy images

Images hosted on other servers:

A: secretary granules, rough endoplasmic reticulum, golgi apparatus
and mitochondria; B: microvilli on luminal surface of epithelial cells
appear to be secretory; C: annulate lamellae composed of parallel
arrays of cisternae have small annuli or fenestrae

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