Skin nontumor
Infectious disorders
CMV


Topic Completed: 1 July 2011

Minor changes: 17 August 2020

Copyright: 2002-2020, PathologyOutlines.com, Inc.

PubMed Search: CMV [title] AND Cytomegalovirus [title]

Mowafak Hamodat, M.B.Ch.B., M.Sc.
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Cite this page: Hamodat M. CMV. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/skinnontumorcmv.html. Accessed October 21st, 2020.
Definition / general
  • CMV belongs to the subgroup of beta herpesviruses
Epidemiology
  • Like other members of the family Herpesviridae, CMV produces primary infections, latent infections and reinfections, although its site of latency is not known
Clinical features
  • Postampicillin maculopapular eruption is most common clinical presentation
  • Presents with urticaria, vesiculobullous lesions, pustular lesions and ulceration (including genital ulcers); also keratotic lesions, diaper dermatitis and even epidermolysis
  • Rarely associated with erythema multiforme (J Cutan Med Surg 2011;15:115)
Treatment
  • Ganciclovir, a guanosine analogue that selectively inhibits CMV DNA polymerase, may be used
Microscopic (histologic) description
  • Nonspecific dermal infiltrate
  • Characteristic changes are enlarged endothelial cells in small dermal vessels; nuclei contain large, eosinophilic inclusions surrounded by a clear halo; cytomegalic changes without nuclear inclusions have been reported
  • May also be prominent neutrophilic infiltration of involved vessel walls, although an unequivocal leukocytoclastic vasculitis is quite rare
  • Fibrocytes, macrophages and rarely ductal epithelial cells may harbor viral inclusions
Microscopic (histologic) images

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Classic owl's eye inclusions

CMV immunostain

Positive stains
  • Monoclonal antibodies to CMV can confirm diagnosis in cases with unusual histopathological changes
  • PCR-based methods are also available
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