Skin nontumor

Infectious disorders

Epidermodysplasia verruciformis

Last author update: 1 July 2011
Last staff update: 19 September 2023

Copyright: 2002-2023,, Inc.

PubMed Search: Epidermodysplasia verruciformis

Nat Pernick, M.D.
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Cite this page: Pernick N. Epidermodysplasia verruciformis. website. Accessed September 21st, 2023.
Definition / general
  • Disorder of multiple flat warts on face or distal extremities, often disseminated throughout the body
Clinical features
  • 30 - 50% progress to invasive squamous cell carcinoma, mean age 31 years
  • Equivocal cases are best distinguished by histology and viral testing, in context of clinical setting
  • Flat, skin colored, red or hyperpigmented papules resembling flat warts or scaly brown pityriasis versicolor-like macules and patches
  • Also seborrheic keratosis-like
  • Excision or locally destructive methods
Clinical images

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Papillomatous and macular lesions

Hypopigmented papules and plaques

Microscopic (histologic) description
  • Classic features are mild to moderate acanthosis and hyperkeratosis
  • Large cells with blue-gray cytoplasm, perinuclear halos, often dysplastic changes, particularly post kidney transplantation (J Cutan Pathol 2002;29:480)
  • More commonly has irregular granular layer with rare perinuclear halos
Microscopic (histologic) images

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Epidermodysplasia verruciformis

Epidermodysplasia verruciformis

Images hosted on other servers:

Various images

Characteristic enlarged keratinocytes with blue-gray pallor; no significant keratinocytic atypia, pleomorphism or mitotic figures

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