Skin nontumor
Dermal perivascular and vasculopathic reaction patterns
Erythema elevatum diutinum

Topic Completed: 1 July 2011

Minor changes: 5 October 2020

Copyright: 2002-2020,, Inc.

PubMed Search: Erythema elevatum diutinum

Nat Pernick, M.D.
Page views in 2019: 2,134
Page views in 2020 to date: 1,630
Cite this page: Pernick N. Erythema elevatum diutinum. website. Accessed October 21st, 2020.
Definition / general
  • Bilaterally symmetric erythematous or violaceous plaques or nodules, often over outer surface of joints
  • Systemically ill patients or associated with HIV
  • May be related to granuloma faciale
  • May be an immune-complex vasculitis induced by chronic antigen exposure
Case reports
Clinical images

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Firm brown tumors on extensor surfaces of extremities

Gross images

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Nodules removed from hand

Microscopic (histologic) description
  • Leukocytoclastic vasculitis, progressing to fibrosis and onion skinning around vessels
  • Extracellular lipid deposits may be present in late lesions; no / rare eosinophils
Microscopic (histologic) images

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Small vessel vasculitis

Whorled fibromatous pattern

Differential diagnosis
  • Localized chronic fibrosing vasculitis: different clinical findings
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