Skin nontumor

Infectious disorders


Last author update: 1 July 2011
Last staff update: 16 November 2020

Copyright: 2002-2023,, Inc.

PubMed Search: Fungi - Zygomycosis [title]

Nat Pernick, M.D.
Page views in 2022: 874
Page views in 2023 to date: 625
Cite this page: Pernick N. Fungi-Zygomycosis. website. Accessed September 27th, 2023.
Clinical features
  • Infections caused by fungi in class Zygomycetes, including Absidia, Mucor, Rhizomucor, Rhizopus, Apophysomyces elegans (rare human pathogen)
  • Most zygomycosis occur in immunocompromised patients (due to leukemia, lymphoma, diabetes, transplantation), with rhinocerebral or pulmonary infection, then dissemination
  • Other causes include iron overload, major trauma, chronic corticosteroids, intravenous drug use / injection abscess (Indian J Med Res 2010;131:765), neonatal prematurity, malnourishment
  • A. elegans causes progressive necrosis of wound in previously healthy patients after trauma or invasive procedures (Arch Pathol Lab Med 1999;123:386)
  • PCR or culture
  • A. elegans - grows as a rapidly growing mold with sporangiophores having dark brown, funnel shaped apophyses and pyriform sporangia
Clinical images

Images hosted on other servers:

Rhizomucor culture has
"cotton candy"-like texture,
grows rapidly, maturation
within 4 days

Rhizomucor culture demonstrates sparsely septate broad hyphae, irregularly branched sporangiophores, brown round sporangia, rhizoids located on stolons between sporangiophores

Microscopic (histologic) description
  • Extensive coagulative necrosis due to fungi with broad, sparsely septate, thin-walled hyphae
  • Angioinvasion with thrombosis
Microscopic (histologic) images

Images hosted on other servers:

Aseptate hyphae

Additional references
Back to top
Image 01 Image 02