Skin nontumor
Dermal collagen and elastic tissue alterations, and cutaneous deposits
Malignant atrophic papulosis

Topic Completed: 1 August 2011

Minor changes: 5 October 2020

Copyright: 2002-2020,, Inc.

PubMed Search: Malignant atrophic papulosis

Mowafak Hamodat, M.B.Ch.B., M.Sc.
Page views in 2019: 609
Page views in 2020 to date: 495
Cite this page: Hamodat M. Malignant atrophic papulosis. website. Accessed October 26th, 2020.
Definition / general
  • Intimal proliferation of deep-seated arterioles which causes infarcts
  • Dego's disease: variant causing a lethal syndrome, involving small bowel, heart, lungs, kidney, bladder and liver
  • Also benign and familiar variants
Clinical features
  • Discrete small patches composed of a central zone with a depressed white, porcelain like appearance and a fine scale surrounded by a narrow red or violaceous rim associated with a fine telangiectasia
  • Skin lesions affect the trunk and proximal extremity
Microscopic (histologic) description
  • Epidermis is hyperkeratotic and atrophic
  • Wedge shaped dermal infarct with the base parallel to the surface epithelium
  • Pale in color, relatively acellular
  • Mucin deposition common
  • Older lesions are frequently ulcerated
  • Vessels adjacent to and deep to the infarct show a perivascular lymphocytic infiltrate
  • Endovasculitis in dermal vessels with endothelial cell hyperplasia and complicated by thrombosis
  • Panniculitis mimicking lupus erythematosus profundus has been described
  • Microscopic examination of bowel reveals transmural intestinal inflammation with ulceration and hemorrhage
Differential diagnosis
Additional references
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