Skin nontumor

Other dermatoses

Massive localized lymphedema

Last author update: 1 August 2011
Last staff update: 31 August 2020

Copyright: 2002-2023,, Inc.

PubMed Search: Massive localized lymphedema [title]

Mowafak Hamodat, M.B.Ch.B., M.Sc.
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Cite this page: Hamodat M. Massive localized lymphedema. website. Accessed September 27th, 2023.
Definition / general
  • Huge masses in thigh, popliteal fossa, scrotum, suprapubic region, inguinal region and abdomen of morbidly obese patients, lasting 1 - 8 years
  • Clinically resembles lipoma or recurrent cellulitis, but also suspicious for malignancy
  • May be due to obstruction of efferent lymphatics by prior surgery, massive abdominal pannus or hypothyroidism
Clinical features
  • Nonencapsulated, poorly defined, mean 51 cm (range 38 - 75 cm), mean weight 6.8 kg (range 2 - 12 kg)
  • Overlying skin has marbled appearance resembling chronic lymphedema with induration and peau díorange
Microscopic (histologic) description
  • Fibrous bands intersect lobules of adipose tissue
  • Lymphatic vascular ectasia, chronic inflammatory infiltrate, edema between collagen fibers, infarction and fat necrosis
  • No atypia
Microscopic (histologic) images

Contributed by Mark R. Wick, M.D.

Differential diagnosis
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