Skin nontumor
Dermal non-granulomatous granulocyte-rich reaction patterns
Neutrophilic eccrine hidradenitis


Topic Completed: 20 July 2020

Minor changes: 20 July 2020

Copyright: 2020, PathologyOutlines.com, Inc.

PubMed Search: Neutrophilic eccrine hidradenitis[TI]

Jasmine Saleh, M.D., M.P.H.
Jodi Speiser, M.D.
Page views in 2020 to date: 354
Cite this page: Saleh J, Speiser J. Neutrophilic eccrine hidradenitis. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/skinnontumorneh.html. Accessed October 21st, 2020.
Definition / general
  • A benign, self limiting chemotherapy associated neutrophilic dermatosis characterized by neutrophilic infiltration of eccrine sweat glands (Case Rep Dermatol 2013;5:340)
Essential features
Sites
Pathophysiology
Etiology
Clinical features
Diagnosis
  • Skin biopsy
Prognostic factors
Case reports
Treatment
Clinical images

Images hosted on other servers:

Violaceous plaques on the upper back

Erythematous plaques on the chest and abdomen

Solitary papules on the forearm

Erythematous, papular lesions on bilateral palms

Microscopic (histologic) description
Microscopic (histologic) images

Contributed by Jasmine Saleh, M.D., M.P.H. and Jodi Speiser, M.D.

Interface dermatitis

Neutrophils and squamous syringometaplasia

Sample pathology report
  • Skin, upper back, biopsy:
    • Neutrophilic eccrine hidradenitis
Differential diagnosis
  • Idiopathic plantar hidradenitis (neutrophilic eccrine hidradenitis in children):
    • Neutrophilic inflammation is centered on the coiled duct and proximal straight duct, with the secretory apparatus usually being spared or only minimally affected
    • Eccrine syringometaplasia is not seen
  • Sweet syndrome:
    • Dense diffuse infiltration of neutrophils in the dermis
    • No eccrine involvement
  • Cellulitis:
    • Diffuse infiltration of neutrophils
    • Positive culture or special stains
    • No eccrine involvement
  • Pyoderma gangrenosum:
    • Nonspecific ulceration with dermal acute and chronic inflammation
    • No eccrine involvement
Board review style question #1

Which of the following is true about neutrophilic eccrine hidradenitis (shown in the image)?

  1. Dermal edema, squamous syringometaplasia and necrosis of the eccrine coils and glands may be present
  2. It is highly malignant with poor prognosis
  3. It most frequently occurs in infants and children after viral infection
  4. It presents as a tan-brown pustule
Board review answer #1
A. Dermal edema, squamous syringometaplasia and necrosis of the eccrine coils and glands may be present

Reference: Neutrophilic eccrine hidradenitis

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Board review style question #2
Which of the following can be seen in neutrophilic eccrine hidradenitis?

  1. Dense diffuse infiltration of neutrophils in the dermis
  2. Mucinous degeneration in periadnexal fibroadipose tissue
  3. Ulceration
  4. Vasculitis
Board review answer #2
B. Mucinous degeneration in periadnexal fibroadipose tissue

Reference: Neutrophilic eccrine hidradenitis

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