Skin nontumor

Dermal collagen and elastic tissue alterations and metabolic disorders

Nephrogenic systemic fibrosis



Last author update: 1 March 2016
Last staff update: 14 July 2023

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PubMed Search: Nephrogenic systemic fibrosis

Nat Pernick, M.D.
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Cite this page: Pernick N. Nephrogenic systemic fibrosis. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/skinnontumornephrosystfibrosis.html. Accessed March 29th, 2024.
Clinical images

Contributed by Joel Pinczewski, M.D., Ph.D.

Indurated and hyperpigmented skin lesions

Microscopic (histologic) description
  • Elastic fibers
    • Known as sclerotic bodies or elastocollagenous balls
    • Originally thought to be pathognomonic of nephrogenic systemic fibrosis, but subsequently described in other lesions in patients exposed to gadolinium
Microscopic (histologic) images

Contributed by Joel Pinczewski, M.D., Ph.D.

Increased dermal mucin and spindled fibroblasts

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