Skin nontumor
Dermal collagen and elastic tissue alterations, and cutaneous deposits
Nephrogenic systemic fibrosis


Topic Completed: 1 March 2016

Minor changes: 5 August 2020

Copyright: 2002-2020, PathologyOutlines.com, Inc.

PubMed Search: Nephrogenic systemic fibrosis

Nat Pernick, M.D.
Page views in 2019: 221
Page views in 2020 to date: 322
Cite this page: Pernick N. Nephrogenic systemic fibrosis. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/skinnontumornephrosystfibrosis.html. Accessed October 21st, 2020.
Clinical images

Contributed by Joel Pinczewski, M.D., Ph.D.

The 53 year old woman in this photograph had end stage renal failure
and underwent a gadolinium enhanced MRI; several years later she developed
indurated and hyperpigmented skin lesions on her lower legs.

Microscopic (histologic) description
  • Elastic fibers:
    • Known as sclerotic bodies or “elastocollagenous balls”
    • Originally thought to be pathognomonic of nephrogenic systemic fibrosis, but subsequently described in other lesions in patients exposed to gadolinium
Microscopic (histologic) images

Contributed by Joel Pinczewski, M.D., Ph.D.

The H&E stained section reveals increased dermal mucin,
spindled fibroblasts and nodules of collagen containing entrapped elastic fibers

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