Skin nontumor
Dermal collagen and elastic tissue alterations, and cutaneous deposits
Nephrogenic systemic fibrosis

Topic Completed: 1 March 2016

Minor changes: 5 August 2020

Copyright: 2002-2020,, Inc.

PubMed Search: Nephrogenic systemic fibrosis

Nat Pernick, M.D.
Page views in 2019: 221
Page views in 2020 to date: 322
Cite this page: Pernick N. Nephrogenic systemic fibrosis. website. Accessed October 21st, 2020.
Clinical images

Contributed by Joel Pinczewski, M.D., Ph.D.

The 53 year old woman in this photograph had end stage renal failure
and underwent a gadolinium enhanced MRI; several years later she developed
indurated and hyperpigmented skin lesions on her lower legs.

Microscopic (histologic) description
  • Elastic fibers:
    • Known as sclerotic bodies or “elastocollagenous balls”
    • Originally thought to be pathognomonic of nephrogenic systemic fibrosis, but subsequently described in other lesions in patients exposed to gadolinium
Microscopic (histologic) images

Contributed by Joel Pinczewski, M.D., Ph.D.

The H&E stained section reveals increased dermal mucin,
spindled fibroblasts and nodules of collagen containing entrapped elastic fibers

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