Skin nontumor
Dermal collagen and elastic tissue alterations, and cutaneous deposits
Nephrogenic systemic fibrosis
Author: Nat Pernick, M.D.
Last author update: 1 March 2016
Last staff update: 14 July 2023
Copyright: 2002-2023, PathologyOutlines.com, Inc.
PubMed Search: Nephrogenic systemic fibrosis
Table of Contents
Clinical images | Microscopic (histologic) description | Microscopic (histologic) imagesCite this page: Pernick N. Nephrogenic systemic fibrosis. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/skinnontumornephrosystfibrosis.html. Accessed October 2nd, 2023.
Clinical images
Contributed by Joel Pinczewski, M.D., Ph.D.
Indurated and hyperpigmented skin lesions
Microscopic (histologic) description
- Elastic fibers
- Known as sclerotic bodies or elastocollagenous balls
- Originally thought to be pathognomonic of nephrogenic systemic fibrosis, but subsequently described in other lesions in patients exposed to gadolinium
Microscopic (histologic) images
Contributed by Joel Pinczewski, M.D., Ph.D.
Increased dermal mucin and spindled fibroblasts
