Skin nontumor
Dermal collagen and elastic tissue alterations, and cutaneous deposits
Nephrogenic systemic fibrosis
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Last staff update: 5 August 2020
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PubMed Search: Nephrogenic systemic fibrosis
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Cite this page: Pernick N. Nephrogenic systemic fibrosis. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/skinnontumornephrosystfibrosis.html. Accessed February 8th, 2023.
Clinical images
Contributed by Joel Pinczewski, M.D., Ph.D.
The 53 year old woman in this photograph had end stage renal failure
and underwent a gadolinium enhanced MRI; several years later she developed
indurated and hyperpigmented skin lesions on her lower legs.
Microscopic (histologic) description
- Elastic fibers:
- Known as sclerotic bodies or “elastocollagenous balls”
- Originally thought to be pathognomonic of nephrogenic systemic fibrosis, but subsequently described in other lesions in patients exposed to gadolinium
Microscopic (histologic) images
Contributed by Joel Pinczewski, M.D., Ph.D.
The H&E stained section reveals increased dermal mucin,
spindled fibroblasts and nodules of collagen containing entrapped elastic fibers
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