Skin nontumor

Dermal collagen and elastic tissue alterations, and cutaneous deposits

Nephrogenic systemic fibrosis

Last author update: 1 March 2016
Last staff update: 14 July 2023

Copyright: 2002-2023,, Inc.

PubMed Search: Nephrogenic systemic fibrosis

Nat Pernick, M.D.
Page views in 2022: 639
Page views in 2023 to date: 612
Cite this page: Pernick N. Nephrogenic systemic fibrosis. website. Accessed October 2nd, 2023.
Clinical images

Contributed by Joel Pinczewski, M.D., Ph.D.

Indurated and hyperpigmented skin lesions

Microscopic (histologic) description
  • Elastic fibers
    • Known as sclerotic bodies or elastocollagenous balls
    • Originally thought to be pathognomonic of nephrogenic systemic fibrosis, but subsequently described in other lesions in patients exposed to gadolinium
Microscopic (histologic) images

Contributed by Joel Pinczewski, M.D., Ph.D.

Increased dermal mucin and spindled fibroblasts

Back to top
Image 01 Image 02