Skin nontumor
Dermal collagen and elastic tissue alterations, and cutaneous deposits
Nephrogenic systemic fibrosis
Author: Nat Pernick, M.D.
Topic Completed: 1 March 2016
Minor changes: 5 August 2020
Copyright: 2002-2020, PathologyOutlines.com, Inc.
PubMed Search: Nephrogenic systemic fibrosis
Table of Contents
Clinical images | Microscopic (histologic) description | Microscopic (histologic) imagesCite this page: Pernick N. Nephrogenic systemic fibrosis. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/skinnontumornephrosystfibrosis.html. Accessed October 21st, 2020.
Clinical images
Contributed by Joel Pinczewski, M.D., Ph.D.
The 53 year old woman in this photograph had end stage renal failure
and underwent a gadolinium enhanced MRI; several years later she developed
indurated and hyperpigmented skin lesions on her lower legs.
Microscopic (histologic) description
- Elastic fibers:
- Known as sclerotic bodies or “elastocollagenous balls”
- Originally thought to be pathognomonic of nephrogenic systemic fibrosis, but subsequently described in other lesions in patients exposed to gadolinium
Microscopic (histologic) images
Contributed by Joel Pinczewski, M.D., Ph.D.
The H&E stained section reveals increased dermal mucin,
spindled fibroblasts and nodules of collagen containing entrapped elastic fibers
