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Synovial metaplasia

Last author update: 1 August 2011
Last staff update: 31 August 2020

Copyright: 2002-2023,, Inc.

PubMed Search: Synovial metaplasia

Mowafak Hamodat, M.B.Ch.B., M.Sc.
Page views in 2022: 1,564
Page views in 2023 to date: 348
Cite this page: Hamodat M. Synovial metaplasia. website. Accessed March 21st, 2023.
Definition / general
  • Metaplastic changes resembling synovium in non-joint spaces, usually in patients with prior surgery or traumatic injuries
  • Synovial-type membranes may form against surface of suture material, tissue expanders or implants
  • Associated with movement, loose areolar tissue that would develop spaces secondary to movement, and relatively smooth gliding surfaces that can resist penetration by fibroblasts (Arch Pathol Lab Med 2002;126:727)
  • Membranes resemble joint (“true”) synovial membranes
  • May be associated with cyst formation and transepidermal fistulae (Am J Surg Pathol 1987;11:343)
Clinical features
  • Resemble suture granulomas
Microscopic (histologic) description
  • Resembles hyperplastic synovium
Positive stains
Negative stains
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