Skin melanocytic tumor
Topics to be merged
Itos nevus

Topic Completed: 1 April 2013

Minor changes: 4 November 2020

Copyright: 2003-2021,, Inc.

PubMed Search: Nevus of Ito [title]

Christopher S. Hale, M.D.
Page views in 2020: 929
Page views in 2021 to date: 731
Cite this page: Hale CS. Itos nevus. website. Accessed July 24th, 2021.
Definition / general
  • First described by Minor Ito in 1954 (Tohoko J Exper Med 1954;60:10)
  • More accurately grouped with "dermal melanocytoses" (nevus of Ito, nevus of Ota, Hori nevus, so-called "Mongolian" spot) (eMedicine: Nevi of Ota and Ito)
  • Although melanocytic, it is NOT a true nevus
  • Different entity from Hypomelanosis of Ito, a neurocutaneous disorder (J Child Neurol 2000;15:635)
  • Usually individuals with pigmented skin, most commonly Asians; also Hispanics, blacks, Native Americans
  • More common in women
  • Often occurs with nevus of Ota in same patient, but is much less common
  • By definition, found in "shawl" or "cloak" distribution
Clinical features
  • Macule with irregular blue-gray pigmentation
  • Similar to nevus of Ota except for location
  • Ito’s nevus is found in shoulder, side of neck and supraclavicular areas, within the distribution of the lateral (also called posterior) supraclavicular nerve and lateral cutaneous brachial nerves
  • Nevus of Ota is found around the eyes
Case reports
Clinical images

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Nevus of Ota (face) and nevus of Ito (shoulder)

Microscopic (histologic) description
  • Deeply pigmented dendritic melanocytes and melanophages dissecting bundles of dermal collagen in reticular dermis
  • Overlying epidermis is normal
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