Skin melanocytic tumor
Spitz neoplasms
Other Spitz nevus variants (angiomatoid, desmoplastic, epithelioid, pagetoid, plexiform)
Author: Christopher S. Hale, M.D.
Topic Completed: 1 March 2013
Minor changes: 8 November 2021
Copyright: 2002-2021, PathologyOutlines.com, Inc.
PubMed Search: Desmoplastic Spitz nevus
See also: Spitz nevus
Table of Contents
Definition / general | Epidemiology | Dermoscopy | Clinical features | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Differential diagnosisCite this page: Hale CS. Other Spitz nevus variants (angiomatoid, desmoplastic, epithelioid, pagetoid, plexiform). PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/skintumormelanocyticdesmoplasticspitz.html. Accessed November 27th, 2021.
Definition / general
- Spitz (spindle and epithelioid cell) nevus with dense eosinophilic stroma
- Other Spitz nevus features present (Kamino bodies, etc.)
- Uncertain relationship to "desmoplastic (sclerotic) nevus" (Am J Dermatopathol 2011;33:35)
Epidemiology
- Mostly young women
Dermoscopy
- Eccentric atypical network and central lacunar white zones, short telangiectatic vessels (Am J Dermatopathol 2011;33:628)
Clinical features
- Solitary papules on limbs of young adults (not a common site for melanoma)
Microscopic (histologic) description
- Resembles classic Spitz nevus (symmetric with inverted wedge shape, infiltration of dermis by relatively bland epithelioid and spindle cells) but dermal fibrosis encircles individual cells and simulates invasion
- Angiomatoid variant exists (Am J Dermatopathol 2000;22:135, Am J Dermatopathol 2002;24:184, J Cutan Pathol 2009;36:471)
Microscopic (histologic) images
AFIP images
Symmetrical
lesion shows
maturation of
lesional cells
Images hosted on other servers:
Melanocytes with spitzoid appearance
Near-dermal lesion
Various images
Various images
Differential diagnosis
