Skin melanocytic tumor

Spitz neoplasms

Other Spitz nevus variants (angiomatoid, desmoplastic, epithelioid, pagetoid, plexiform)

Topic Completed: 1 March 2013

Minor changes: 8 November 2021

Copyright: 2002-2021,, Inc.

PubMed Search: Desmoplastic Spitz nevus

See also: Spitz nevus

Christopher S. Hale, M.D.
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Cite this page: Hale CS. Other Spitz nevus variants (angiomatoid, desmoplastic, epithelioid, pagetoid, plexiform). website. Accessed November 27th, 2021.
Definition / general
  • Spitz (spindle and epithelioid cell) nevus with dense eosinophilic stroma
  • Other Spitz nevus features present (Kamino bodies, etc.)
  • Uncertain relationship to "desmoplastic (sclerotic) nevus" (Am J Dermatopathol 2011;33:35)
  • Mostly young women
Clinical features
  • Solitary papules on limbs of young adults (not a common site for melanoma)
Microscopic (histologic) description
Microscopic (histologic) images

AFIP images

lesion shows
maturation of
lesional cells

Images hosted on other servers:

Melanocytes with spitzoid appearance

Near-dermal lesion

Various images

Various images

Positive stains
Differential diagnosis
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