Skin melanocytic tumor
Spitzoid neoplasms, BAP1 inactivated neoplasms, and deep penetrating nevi
Other Spitz nevus variants (angiomatoid, desmoplastic, epithelioid, pagetoid, plexiform)

Topic Completed: 1 March 2013

Minor changes: 15 May 2019

Copyright: 2002-2019,, Inc.

PubMed Search: Desmoplastic Spitz nevus

See also Spitz nevus

Christopher S. Hale, M.D.
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Page views in 2020 to date: 777
Cite this page: Hale C. Other Spitz nevus variants (angiomatoid, desmoplastic, epithelioid, pagetoid, plexiform). website. Accessed August 6th, 2020.
Definition / general
  • Spitz (spindle and epithelioid cell) nevus with dense eosinophilic stroma
  • Other Spitz nevus features present (Kamino bodies, etc.)
  • Uncertain relationship to "desmoplastic (sclerotic) nevus" (Am J Dermatopathol 2011;33:35)
  • Mostly young women
Clinical features
  • Solitary papules on limbs of young adults (not a common site for melanoma)
Microscopic (histologic) description
Microscopic (histologic) images

AFIP Images

Symmetrical lesion shows maturation of lesional cells in the dermis with attenuated single cells
among reticular dermis collagen bundles at the base but unlike desmoplastic melanoma, the
intraepidermal component does not extend substantially beyond the dermal component and
there are no clusters of mitotically active epithelioid melanocytes in the superficial dermis

Images hosted on other servers:

Melanocytes with spitzoid appearance

Near-dermal lesion

Various images

Various images

Positive stains
Differential diagnosis
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