Skin melanocytic tumor
Topics to be merged
Lentiginous melanoma

Topic Completed: 1 May 2013

Minor changes: 22 September 2020

Copyright: 2002-2021,, Inc.

PubMed Search: Lentiginous melanoma

Christopher S. Hale, M.D.
Page views in 2020: 2,259
Page views in 2021 to date: 565
Cite this page: Hale CS. Lentiginous melanoma. website. Accessed March 5th, 2021.
Definition / general
  • Rare subset of slowly progressing, radial growth phase melanoma with lentiginous proliferation of moderately atypical epithelioid melanocytes, focal pagetoid spread and nesting; not associated with architectural changes at dermoepidermal junction (Arch Pathol Lab Med 2011;135:337)
  • First described in 2005 (Mod Pathol 2005;18:1397)
  • May remain in situ for prolonged periods before invasion
  • May be an analogue of lentigo maligna on mild / moderately sun damaged skin (J Cutan Pathol 2007;34:296)
  • May recur locally
  • Distinct from acral lentiginous melanoma, lentigo maligna and superficial spreading melanoma
Microscopic (histologic) description
  • Broad lentiginous proliferation of melanocytes at dermoepidermal junction, both as single cells and as small nests with areas of confluent growth, extending to edges of biopsy
  • Prominent atypia of melanocytes and invasion may be evident only at excision
  • Preservation of retiform epidermis
  • Similar to other histologic subtypes with a lentiginous junctional proliferation (lentigo maligna, acral lentiginous and mucosal lentiginous)
  • Variable dermal fibrosis
  • No solar elastosis
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