Skin melanocytic tumor
Topics to be merged
Primary dermal melanoma

Topic Completed: 1 May 2013

Minor changes: 14 April 2021

Copyright: 2002-2021,, Inc.

PubMed Search: Primary dermal melanoma

Christopher S. Hale, M.D.
Page views in 2020: 1,818
Page views in 2021 to date: 949
Cite this page: Hale CS. Primary dermal melanoma. website. Accessed May 16th, 2021.
Definition / general
  • Extremely rare
  • Melanoma subtype confined to dermis or subcutis
  • No apparent site predilection
Clinical features
  • Solitary and well circumscribed but unencapsulated, deep dermal or subcutaneous melanoma
Case reports
  • Prolonged survival (Arch Dermatol 2004;140:99) compared to melanoma of similar thickness but may recur or develop metastases
  • Lack of atypical pigmented network and radial streaks; papillomatous projections with light brown and dark brown blotchy areas (Am J Dermatopathol 2009;31:574)
Clinical images

Images hosted on other servers:

Blue nodule on arm

Slightly bluish scalp nodule

Microscopic (histologic) description
  • Melanoma confined to dermis or subcutis; mean Breslow depth is 1 cm
  • No in situ component, regression or ulceration
  • No associated nevus
Microscopic (histologic) images

Images hosted on other servers:

Various images

Metastatic melanoma versus primary dermal melanoma

Positive stains
Molecular / cytogenetics description
  • Strong expression of KIT (CD117) by immunohistochemistry but no EWS / ATF1 fusion transcript (J Dermatol 2009;36:346)
Differential diagnosis
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