Skin nonmelanocytic tumor

Premalignant / in situ

Bowenoid papulosis



Topic Completed: 1 June 2012

Minor changes: 14 October 2020

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PubMed Search: Bowenoid papulosis

Christopher S. Hale, M.D.
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Cite this page: Hale C. Bowenoid papulosis. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/skintumornonmelanocyticbowenoidpapulosis.html. Accessed October 20th, 2021.
Definition / general
  • Multiple pigmented papular lesions of anogenital area, usually in young adults, resembling condyloma acuminatum
  • May regress spontaneously
  • Almost never invasive
Case reports
Clinical images

Images hosted on other servers:

Penile shaft

Gross description
  • Flat papules on anogenital skin
Microscopic (histologic) description
  • Resembles carcinoma in situ, but with localized acanthosis similar to condylomas
  • Low power view is “salt and pepper” due to dark nuclei and clear vacuolar cytoplasm
  • Usually no adnexal involvement
Microscopic (histologic) images

Images hosted on other servers:

Acanthosis and dyskeratosis

Positive stains
Molecular / cytogenetics description
  • HPV type 16 is most common
Differential diagnosis
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