Skin nonmelanocytic tumor
Lymphoma and related disorders (see also Lymphoma chapter)

Topic Completed: 1 June 2012

Minor changes: 15 October 2020

Copyright: 2001-2020,, Inc.

PubMed search: cutaneous [title] OR dermal [title] lymphoma skin

Christopher S. Hale, M.D.
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Cite this page: Hale C. General. website. Accessed October 21st, 2020.
Definition / general
  • See also Lymphoma chapter
  • Equal incidence of B and T cell disorders (noncutaneous lymphomas have B cell predominance)
  • May be primary to skin or part of systemic disease
  • Common primary cutaneous lymphomas are: T cell - mycosis fungoides; B cell - diffuse large B cell lymphoma, extranodal marginal zone lymphoma, follicular lymphoma
  • Note: lymphocytes in skin are significant, since not usually present, although may be due to dermatoses
  • Angiocentric: lymphomatoid granulomatosis, nasal type NK / T cell lymphoma
  • Dermal involvement: blastic NK cell lymphoma, CD30+/- large T cell lymphoma, diffuse large B cell lymphoma, follicular center cell lymphoma, granulomatous slack skin disease, inflammatory pseudotumor, lymphoid hyperplasia, lymphomatoid papulosis, marginal zone lymphoma, plasmacytoma, pleomorphic small / medium sized T cell lymphoma
  • Dermal - superficial: Sézary syndrome
  • Epidermotropic: adult T cell leukemia / lymphoma, mycosis fungoides, mycosis fungoides associated follicular mucinosis, pagetoid reticulosis
  • Intravascular: intravascular large B cell lymphoma
  • Subcutaneous: subcutaneous panniculitis-like T cell lymphoma
Microscopic (histologic) description
  • B cell lymphomas: triangular architecture with base in subcutis, compact and nodular infiltrates with perivascular cuffing; epidermis not involved
  • T cell lymphomas: heterogenous; may have epidermal involvement; may have large reactive component mixed with tumor cells
Additional references
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