Skin nonmelanocytic tumor
Lymphoma and related disorders (see also Lymphoma chapter)
B cell neoplasms
Primary cutaneous diffuse large B cell lymphoma

Topic Completed: 1 June 2012

Minor changes: 15 January 2021

Copyright: 2003-2021,, Inc.

PubMed search: Diffuse large B-cell lymphoma [title] skin

Related topics: Leg type

Christopher S. Hale, M.D.
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Cite this page: Hale CS. Primary cutaneous diffuse large B cell lymphoma. website. Accessed January 22nd, 2021.
Definition / general
Case reports
  • 51 and 62 year old men with primary cutaneous T cell-rich B cell lymphoma (Mod Pathol 2001;14:10)
  • T(14;18)(q32;q21) involving MALT1 and IGH genes in an extranodal diffuse large B cell lymphoma (Hum Pathol 2003;34:1212)
  • Surgery, localized radiotherapy
  • Systemic chemotherapy only for generalized skin lesions or disseminated lesions
Gross description
  • Solitary or grouped papules, plaques or tumors, usually in head, neck and trunk of older patients
Microscopic (histologic) description
  • Either:
    • Mixed large and small B cells
    • Grade 3 follicular lymphomas (usually in head / neck and CD10+) OR
    • Monomorphous large cell (Am J Surg Pathol 2001;25:307)
Microscopic (histologic) images

Contributed by Mark R. Wick, M.D.

Various images

Images hosted on other servers:

Diffusely dense lymphocytic infiltrate

Positive stains
Negative stains
  • Tumor cells: CD3 (positive in background cells), CD10 (usually)
Flow cytometry description
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