Skin nonmelanocytic tumor
Fibrous, fibrohistiocytic and myofibroblastic neoplasms
Keloid
Author: Christopher S. Hale, M.D.
Last author update: 1 September 2012
Last staff update: 13 March 2023 (update in progress)
Copyright: 2003-2023, PathologyOutlines.com, Inc.
PubMed search: Keloid [title] skin
Table of Contents
Definition / general | Treatment | Clinical images | Microscopic (histologic) description | Microscopic (histologic) images | Molecular / cytogenetics description | Differential diagnosisCite this page: Hale CS. Keloid. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/skintumornonmelanocytickeloid.html. Accessed March 26th, 2023.
Definition / general
- Abnormal fibroblast reaction to injury
- Usually in people of African descent, often in earlobe
- High rate of recurrence after excision
Treatment
- Corticosteroid injection
Clinical images
Contributed by Mark R. Wick, M.D.
Breast skin
Microscopic (histologic) description
- Wide bands of collagen with large, brightly eosinophilic, glassy fibers
- Also parallel fibroblasts and myofibroblasts
- Mucinous pools after steroid injection
Microscopic (histologic) images
Contributed by Mark R. Wick, M.D.
Molecular / cytogenetics description
- Epigenetic alteration in fibroblast DNA and acetylation of histone proteins (J Invest Dermatol 2010;130:2489)
Differential diagnosis
- Complication of acne
- Hyperplastic scar
- Keloidal dermatofibroma
