Skin nonmelanocytic tumor
Vascular tumors
Kimuras disease
Author: Christopher S. Hale, M.D.
Topic Completed: 1 July 2015
Minor changes: 14 October 2020
Copyright: 2003-2016, PathologyOutlines.com, Inc.
PubMed search: Kimura's disease [title] skin
Table of Contents
Definition / general | Case reports | Clinical images | Gross description | Microscopic (histologic) description | Microscopic (histologic) images | Differential diagnosisCite this page: Hale C. Kimuras disease. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/skintumornonmelanocytickimura.html. Accessed October 21st, 2020.
Definition / general
- Rare chronic inflammatory disorder of deep subcutaneous tissue, etiology unknown (Arch Pathol Lab Med 2007;131:650)
- Usually head and neck, often associated with regional lymphadenopathy or salivary gland involvement
- Usually affects Asian males, but similar presentation in US (Am J Surg Pathol 2004;28:505)
- Almost always affects nodal sites; often associated dermal involvement
- Usually peripheral blood eosinophilia and elevated serum IgE
- Benign and reactive
- May recur, no / rare death from disease
Case reports
- 5 year old boy with asymptomatic solitary brown pigmented nodule on left buttock (Ann Dermatol 2010;22:57)
Clinical images
Images hosted on other servers:
Lesion on buttock
Gross description
- Large tumor-like lesions
Microscopic (histologic) description
- Lymph nodes have preserved architecture, but also follicular hyperplasia, prominent eosinophilic infiltrates, proliferation of postcapillary venules
- Marked fibrosis in advanced stage disease
Microscopic (histologic) images
Images hosted on PathOut server:
Images hosted on other servers:
Courtesy of Dr. Mark R. Wick
Images hosted on other servers:
Various images
Differential diagnosis
- Angiolymphoid hyperplasia with eosinophilia / epithelioid hemangioma
- Hypersensitivity or drug reactions
- Infections
