Skin nonmelanocytic tumor

Carcinoma (nonadnexal)

Mucoepidermoid carcinoma

Topic Completed: 1 November 2014

Minor changes: 2 November 2020

Copyright: 2002-2022,, Inc.

PubMed Search: Mucoepidermoid carcinoma [title] skin

Ghassan A. Tranesh, M.D.
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Cite this page: Tranesh G. Mucoepidermoid carcinoma. website. Accessed January 23rd, 2022.
Definition / general
  • Very rare in skin (~30 cases reported)
  • Probable sweat gland origin
  • Resembles similar tumor of salivary gland
  • Usually low to intermediate grade, some higher grade tumors perhaps better classified as adenosquamous carcinoma
Case reports
Gross description
  • Up to 0.6 cm, ulcerated and nonencapsulated
  • Flesh colored nodules, painless
Gross images

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High grade

Microscopic (histologic) description
  • Circumscribed tumor, may not be attached to surface
  • Multilobulated nodulocystic tumor extending throughout dermis, exhibiting glandular and squamoid differentiation
  • Dermal lobules or cystic growth of low grade epidermoid, intermediate, mucinous cells and clear cells
  • Cribiform nests of epidermoid cells contain glandular spaces with mucin
  • Nuclei are mildly atypical and contain scattered mitotic figures
  • Peritumoral fibrosis is common
  • May have focal perineural invasion
Microscopic (histologic) images

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Site unknown

Salivary gland Alcian blue-PAS

Salivary gland

Cytology images

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Salivary gland

Positive stains
Negative stains
Molecular / cytogenetics description
  • CRTC1 rearrangements have been detected in cutaneous MEC (like salivary gland MEC), but translocation t(11,19) or MAML2 rearrangements not seen (unlike salivary gland MEC) (Br J Dermatol 2009;161:925)
Differential diagnosis
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