Table of ContentsDefinition / general | Case reports | Microscopic (histologic) description | Microscopic (histologic) images | Positive stains | Negative stains
Cite this page: Hale CS. Sinus histiocytosis with massive lymphadenopathy. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/skintumornonmelanocyticsinushistiocytosis.html. Accessed October 29th, 2020.
Definition / general
- Very rare disorder, usually prominent cervical lymphadenopathy, but may involve skin
- Also called Rosai-Dorfman disease
Microscopic (histologic) description
- Infiltration by sheets of large histiocytes with granular eosinophilic cytoplasm, large, round and vesicular nuclei, prominent nucleoli, and accompanied by plasma cells and lymphocytes, emperipolesis (histiocytes with intracytoplasmic lymphocytes)
Microscopic (histologic) images