Skin nonmelanocytic tumor
Lymphoma and related disorders (see also Lymphoma chapter)
Sinus histiocytosis with massive lymphadenopathy

Topic Completed: 1 September 2012

Minor changes: 15 October 2020

Copyright: 2001-2020,, Inc.

PubMed search: sinus histiocytosis [title] massive lymphadenopathy, rosai-dorfman disease [title] skin

Christopher S. Hale, M.D.
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Cite this page: Hale CS. Sinus histiocytosis with massive lymphadenopathy. website. Accessed October 29th, 2020.
Definition / general
  • Very rare disorder, usually prominent cervical lymphadenopathy, but may involve skin
  • Also called Rosai-Dorfman disease
Case reports
Microscopic (histologic) description
  • Infiltration by sheets of large histiocytes with granular eosinophilic cytoplasm, large, round and vesicular nuclei, prominent nucleoli, and accompanied by plasma cells and lymphocytes, emperipolesis (histiocytes with intracytoplasmic lymphocytes)
Microscopic (histologic) images

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Hematoxylin and eosin stain of incisional biopsy

Positive stains
Negative stains
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