Skin nonmelanocytic tumor
Adnexal tumors
Sweat gland derived (apocrine & eccrine glands)

Topic Completed: 1 March 2017

Minor changes: 5 February 2021

Copyright: 2002-2021,, Inc.

PubMed Search: Syringoma [title]

Sara C. Shalin, M.D., Ph.D.
Page views in 2020: 13,096
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Cite this page: Shalin S. Syringoma. website. Accessed March 5th, 2021.
Definition / general
  • Most common clinical presentation on lower eyelids of women
  • Also face, neck, vulva and dorsal, proximal and middle phalanges of hand (Dermatoendocrinol 2009;1:282); also eruptive forms (see eruptive syringoma below)
  • Four clinical variants:
    • Localized
    • Familial
    • Down syndrome associated
    • Generalized (multiple and eruptive)
  • Appears to derive from sweat duct ridge
  • Malignant counterpart can be termed syringomatous carcinoma / sweat gland carcinoma

Eruptive syringoma
  • Neck, anterior trunk, axilla, shoulder, anterior surfaces of arms, abdomen or pubic areas of young men or women
  • May be reactive hyperplasia of eccrine glands, not neoplastic
Case reports
Eruptive syringoma
  • Benign lesions do not require treatment but numerous lesions may be cosmetically concerning
  • Local destructive methods to remove lesions: laser, dermabrasion, biopsy / removal, electrocoagulation
Clinical images

Images hosted on other servers:

Disseminated brownish papules

Eruptive syringoma:
multiple flat papules
on thighs

Gross description
  • Flesh color to yellow, papular lesions, 1 - 3 mm
  • Generally multiple
Microscopic (histologic) description
  • Generally confined to the upper / superficial dermis and circumscribed / symmetric
  • Composed of small ducts with narrow to slightly dilated lumen lined by two layer thick epithelium, often with comma shaped extensions (also referred to "paisley tie" pattern or "tadpole" pattern)
  • May have clear cells (due to glycogen accumulation); clear cell syringoma is associated with diabetes
  • Not infiltrative, no atypia, no mitotic figures, no local destruction
  • Presence of infiltrative growth, desmoplastic stroma, destruction of normal dermal structures or epidermal involvement should prompt consideration of syringomatous carcinoma or other sweat gland derived carcinoma
Microscopic (histologic) images

Contributed by Angel Fernandez-Flores, M.D., Ph.D.

Various images

Images hosted on other servers:

Severe pruritus

Representative lesion

Facial syringoma

Amorphous material

Epithelial cords

Syringomatous pattern

Eruptive syringoma

Positive stains
  • Immunohistochemistry generally not required for diagnosis
  • Usually ductal lumens mark with CEA
  • Often progesterone receptor positive
Electron microscopy description
  • Eccrine origin
Molecular / cytogenetics description
Differential diagnosis
Differential Diagnosis: Clinical:
Differential Diagnosis: Clinical:
Additional references
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