Small intestine & ampulla


MALT lymphoma

Topic Completed: 1 August 2012

Minor changes: 19 November 2020

Copyright: 2003-2021,, Inc.

PubMed Search: MALT lymphoma[TIAB] small bowel

Hanni Gulwani, M.B.B.S.
Page views in 2020: 3,808
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Cite this page: Gulwani H. MALT lymphoma. website. Accessed November 27th, 2021.
Definition / general
  • Tumor of Mucosa Associated Lymphoid Tissue; a type of marginal cell lymphoma
  • More common in stomach than small bowel
  • Often relapses in GI tract only
  • In adults, occurs anywhere in gut but only rarely in appendix and esophagus
  • Initially a type of hyperplasia, then monoclonal T cell dependent (from H. pylori infection), then T cell independent
  • Initial stages may be "cured" by antibiotics or surgery
Case reports
Microscopic (histologic) description
Low grade:
  • Small or monocytoid lymphocytes with irregular nuclei that form lymphoepithelial lesions
  • Reactive germinal centers and plasmacytoid cells are common

High grade:
  • Resembles diffuse large B cell lymphoma but may have Reed-Sternberg like cells
Microscopic (histologic) images

Images hosted on other servers:

Various images

Positive stains
Negative stains
Molecular / cytogenetics description
  • t(11;18) involving c-Myc is common
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