Small intestine & ampulla
Neuroendocrine carcinoma

Topic Completed: 1 August 2012

Minor changes: 19 November 2020

Copyright: 2003-2021,, Inc.

PubMed Search: Neuroendocrine carcinoma[TIAB] small bowel

Hanni Gulwani, M.B.B.S.
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Cite this page: Gulwani H. Neuroendocrine carcinoma. website. Accessed May 15th, 2021.
Definition / general
  • Usually fatal
Case reports
Clinical features
Microscopic (histologic) description
  • Marked pleomorphism, large irregular hyperchromatic nuclei, prominent nucleoli, tumor necrosis, frequent mitotic figures
  • Large cell carcinoma:
    • Islands and trabeculae of large cells with brisk mitotic activity and extensive necrosis
    • Cells have more cytoplasm than small cell carcinoma, irregular chromatin, frequent nucleoli
  • Small cell carcinoma:
    • Sheets and nests of small, round cells with scanty cytoplasm, hyperchromatic nuclei, stippled chromatin, indistinct nucleoli, numerous mitotic figures and apoptotic cells
    • Foci of necrosis and vascular invasion common
    • Resembles pulmonary tumor
    • Pure or mixed with adenocarcinoma
Microscopic (histologic) images

Case #322

Mixed adenoneuroendocrine carcinoma
Line 2: CDX2 (left); chromogranin (middle); synaptophysin (right)

Images hosted on other servers:

Large cell neuroendocrine carcinoma

Small cell neuroendocrine carcinoma

Nests of small cells
with uniform round
nuclei with classic salt
and pepper chromatin

Electron microscopy description
  • Small cell carcinoma: membrane bound dense core granules
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