Small intestine & ampulla
General
WHO classification
Author: Raul S. Gonzalez, M.D.
Editor-in-Chief: Debra L. Zynger, M.D.
Last author update: 10 December 2020
Last staff update: 22 February 2024
Copyright: 2020-2024, PathologyOutlines.com, Inc.
PubMed Search: WHO classification small intestine & ampulla
Cite this page: Gonzalez RS. WHO classification. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/smallbowelWHOclassification.html. Accessed April 20th, 2024.
Definition / general
- WHO classification of tumors of the small intestine and ampulla
- Currently on 5th edition, published in 2019
- Based on histologic appearance, not molecular characteristics
WHO (2019)
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Benign epithelial tumors and precursors ICD-O codes
- Adenomatous polyp, low grade dysplasia 8210/0
- Adenomatous polyp, high grade dysplasia 8210/2
- Intestinal type adenoma, low grade 8144/0
- Intestinal type adenoma, high grade 8144/2
- Serrated dysplasia, low grade 8213/0
- Serrated dysplasia, high grade 8213/2
- Noninvasive pancreatobiliary papillary neoplasm with low grade dysplasia 8163/0
- Noninvasive pancreatobiliary papillary neoplasm with high grade dysplasia 8163/2
- Intra-ampullary papillary tubular neoplasm
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Malignant epithelial tumors ICD-O codes
- Adenocarcinoma, NOS 8140/3
- Mucinous adenocarcinoma 8480/3
- Signet ring cell carcinoma 8490/3
- Medullary carcinoma, NOS 8510/3
- Adenocarcinoma, intestinal type 8144/3
- Pancreatobiliary type adenocarcinoma 8163/3
- Tubular adenocarcinoma 8211/3
- Neuroendocrine tumor, NOS 8240/3
- Neuroendocrine tumor, grade 1 8240/3
- Neuroendocrine tumor, grade 2 8249/3
- Neuroendocrine tumor, grade 3 8249/3
- Gastrinoma, NOS 8153/3
- Somatostatinoma, NOS 8156/3
- Enterochromaffin cell carcinoid 8241/3
- Extra-adrenal paraganglioma, NOS 8693/3
- Neuroendocrine carcinoma, NOS 8246/3
- Large cell neuroendocrine carcinoma 8013/3
- Small cell neuroendocrine carcinoma 8041/3
- Mixed neuroendocrine - nonneuroendocrine neoplasm (MiNEN) 8154/3
