Small bowel (small intestine)
Chronic idiopathic intestinal pseudo-obstruction

Topic Completed: 1 August 2012

Minor changes: 12 March 2019

Copyright: 2003-2019,, Inc.

PubMed Search: Chronic idiopathic intestinal pseudo-obstruction[TIAB]

Hanni Gulwani, M.B.B.S.
Page views in 2019: 277
Page views in 2020 to date: 134
Table of Contents
Definition / general | Etiology
Cite this page: Gulwani H. Chronic idiopathic intestinal pseudo-obstruction. website. Accessed May 24th, 2020.
Definition / general
  • Symptoms of intestinal obstruction without mechanical obstruction
  • Attributed to abnormal physiology of gut propulsive system
  • Local manifestation of generalized disease: diabetes, hypoparathyroidism, Parkinson disease, SLE
  • Diseases with intestinal pathology: amyloidosis, Chagas disease, dermatomyositis / polymyositis, Duchenne muscular dystrophy, myotonic dystrophy, myxedema, scleroderma
  • Also drugs (anti-Parkinson, clonidine, mushroom poisoning), pheochromocytoma, psychosis
  • May be due to marked reduction in interstitial cells of Cajal (Am J Surg Pathol 2003;27:228)
  • By definition, excludes known mechanical causes of obstruction: cathartic colon, ceroidosis, Hirschsprung disease, visceral myopathies (muscle cell degeneration / loss, fibrosis of muscularis propria), visceral neuropathies (familial - Am J Surg Pathol 2010;34:1528, sporadic; require special techniques to demonstrate)
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