Small intestine & ampulla

Congenital anomalies

Common variable immunodeficiency syndrome

Last author update: 1 August 2012
Last staff update: 1 June 2022

Copyright: 2003-2024,, Inc.

PubMed Search: Common variable immunodeficiency syndrome small bowel

Hanni Gulwani, M.B.B.S.
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Cite this page: Gulwani H. Common variable immunodeficiency syndrome. website. Accessed April 14th, 2024.
Definition / general
Clinical features
  • Chronic diarrhea, malabsorption, recurrent GI giardiasis
Case reports
  • 73 year old man with nonspecific abdominal pain (Case #398)
Microscopic (histologic) description
  • Mucosa may resemble celiac sprue or be normal but always has reduced plasma cells and no IgA plasma cells
  • May have lymphoid hyperplasia or apoptotic bodies in crypts
  • Histologic patterns: lymphocytic colitis, collagenous enterocolitis, celiac disease, granulomatous disease, acute GVHD and IBD (Am J Surg Pathol 2007;31:1800)
Microscopic (histologic) images

Case #398

H&E images

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Common variable immunodeficiency syndrome

Common variable immunodeficiency syndrome

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