Small intestine & ampulla
Congenital anomalies
Common variable immunodeficiency syndrome
Author: Hanni Gulwani, M.B.B.S.
Last author update: 1 August 2012
Last staff update: 1 June 2022
Copyright: 2003-2023, PathologyOutlines.com, Inc.
PubMed Search: Common variable immunodeficiency syndrome small bowel
Table of Contents
Definition / general | Clinical features | Case reports | Microscopic (histologic) description | Microscopic (histologic) imagesCite this page: Gulwani H. Common variable immunodeficiency syndrome. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/smallbowelcommonvariable.html. Accessed June 2nd, 2023.
Definition / general
- Primary immune defect (usually genetic) causing reduction in B cells and most immunoglobulin classes; also frequent bacterial infections (eMedicine: Common Variable Immunodeficiency [Accessed 16 February 2018])
Clinical features
- Chronic diarrhea, malabsorption, recurrent GI giardiasis
Case reports
- 73 year old man with nonspecific abdominal pain (Case #398)
Microscopic (histologic) description
- Mucosa may resemble celiac sprue or be normal but always has reduced plasma cells and no IgA plasma cells
- May have lymphoid hyperplasia or apoptotic bodies in crypts
- Histologic patterns: lymphocytic colitis, collagenous enterocolitis, celiac disease, granulomatous disease, acute GVHD and IBD (Am J Surg Pathol 2007;31:1800)
Microscopic (histologic) images
Case #398
H&E images
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Common variable immunodeficiency syndrome
