Small intestine & ampulla

Congenital anomalies

Common variable immunodeficiency syndrome

Topic Completed: 1 August 2012

Minor changes: 18 November 2020

Copyright: 2003-2021,, Inc.

PubMed Search: Common variable immunodeficiency syndrome small bowel

Hanni Gulwani, M.B.B.S.
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Cite this page: Gulwani H. Common variable immunodeficiency syndrome. website. Accessed December 6th, 2021.
Definition / general
Clinical features
  • Chronic diarrhea, malabsorption, recurrent GI giardiasis
Case reports
Microscopic (histologic) description
  • Mucosa may resemble celiac sprue or be normal but always has reduced plasma cells and no IgA plasma cells
  • May have lymphoid hyperplasia or apoptotic bodies in crypts
  • Histologic patterns: lymphocytic colitis, collagenous enterocolitis, celiac disease, granulomatous disease, acute GVHD and IBD (Am J Surg Pathol 2007;31:1800)
Microscopic (histologic) images

Case #398

H&E images

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