Small intestine & ampulla

Infectious disorders

Entamoeba histolytica



Topic Completed: 1 August 2012

Minor changes: 19 November 2020

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PubMed Search: Entamoeba histolytica small bowel

Hanni Gulwani, M.B.B.S.
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Cite this page: Gulwani H. Entamoeba histolytica. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/smallbowelentamoeba.html. Accessed December 8th, 2021.
Definition / general
  • Dysentery causing protozoa that can also cause fulminant colitis; causes up to 100,000 deaths per year (Trop Biomed 2011;28:194)
  • Increased incidence in homosexual men and AIDS patients
Pathophysiology
  • Fecal oral spread
  • Amoeba invade colonic crypts, burrow into lamina propria, create flask shaped ulcer with broad base
  • 40% invade portal vessels, embolize to liver and cause abscesses up to 10 cm
  • May activate apoptosis in target cells (Trends Parasitol 2011;27:254)
  • Rare abscesses in lung, heart, kidneys, brain
Diagrams / tables

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Life cycle

Microscopic (histologic) images

Contributed by Hanni Gulwani, M.D.
Amoebic colitis, numerous trophozoites of amoeba are noted Amoebic colitis, numerous trophozoites of amoeba are noted

Amoebic colitis, numerous trophozoites of amoeba are noted

Amoebic colitis, PAS stain Amoebic colitis, PAS stain

Amoebic colitis, PAS stain



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