Small intestine & ampulla
Inflammatory disorders
Eosinophilic enteritis / gastroenteritis

Topic Completed: 1 August 2012

Minor changes: 19 January 2021

Copyright: 2003-2021,, Inc.

PubMed Search: Eosinophilic enteritis gastroenteritis small bowel

Hanni Gulwani, M.B.B.S.
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Cite this page: Gulwani H. Eosinophilic enteritis / gastroenteritis. website. Accessed May 17th, 2021.
Definition / general
  • Rare disease that may present as obstruction, associated with peripheral eosinophilia and allergic symptoms in children or young adults (Rev Esp Enferm Dig 2004;96:279, Ann Acad Med Singapore 2011;40:379, Ital J Pediatr 2011;37:18)
  • Nausea, vomiting, diarrhea, steatorrhea, protein losing enteropathy
  • Symptoms are related to site of infiltration: mucosa of stomach / small bowel - diarrhea and malabsorption; submucosa and muscularis propria - obstruction; subserosa - ascites
Microscopic (histologic) description
  • Marked eosinophilic infiltration of bowel wall (> 20 eosinophils/HPF in at least one focus), prominent vessels, occasionally necrotizing granulomas and vasculitis
  • Eosinophils typically not associated with other inflammatory cells
  • Infiltration may be patchy
Microscopic (histologic) images

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Differential diagnosis
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