Small intestine & ampulla
Benign tumors / tumor-like conditions
Inflammatory fibroid polyp

Topic Completed: 1 August 2012

Minor changes: 19 November 2020

Copyright: 2003-2021,, Inc.

PubMed Search: Inflammatory fibroid polyp small bowel

Hanni Gulwani, M.B.B.S.
Page views in 2020: 3,091
Page views in 2021 to date: 1,060
Cite this page: Gulwani H. Inflammatory fibroid polyp. website. Accessed May 15th, 2021.
Definition / general
Case reports
  • Excision (does not recur)
Gross description
  • Polypoid (without stalk), submucosal mass, dumbbell shape in small intestine due to intussuception, mucosal ulceration and splitting and atrophy of muscularis propria
Gross images

Contributed by Claudia Mendez, M.D.

Inflammatory fibroid polyp

Microscopic (histologic) description
  • Submucosal mixture of prominent capillaries, spindle cells (occasionally concentrically arranged around vessels / onion skinning) and inflammatory cells (particularly eosinophils, plasma cells and mast cells) in granulation tissue-like stroma (Arch Pathol Lab Med 2010;134:378)
  • May be transmural
  • May have lymphoid follicles
  • Rare multinucleated giant cells, no atypia, no / rare mitotic figures
  • Histologic patterns: classical, edematous, fibrovascular, nodular, sclerotic
Microscopic (histologic) images

Contributed by Claudia Mendez, M.D.




Positive stains
Negative stains
  • CD117 (although mast cells are positive)
Differential diagnosis
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